More research is needed to understand if diosmin aids back pain compared with more established treatments. However, compared with a control group taking mannitol and dexamethasone, diosmin was not more effective at reducing subjective back pain ( 25). In one study, 300 people reported minor improvements in back pain after taking 900 mg of diosmin 3 times daily for 2 weeks, followed by the same dose twice daily for 2 weeks, then a maintenance dose of 450 mg twice daily for 1 month ( 25). Though diosmin may reduce symptoms of CVD, it’s best to speak to a healthcare professional before supplementing with it. Other studies report similar findings ( 22, 23, 24). Still, a 2017 study in 1,051 people noted that diosmin wasn’t as effective at treating CVD symptoms as other medications, such as Venoruton (Novartis) and Pycnogenol (pine bark extract). Furthermore, they showed diosmin reduced leg heaviness, swelling, cramps, and restless leg syndrome ( 17, 18).ĭiosmin treats CVD by reducing inflammation, improving the health of veins, and increasing blood and lymphatic circulation ( 3, 19, 20, 21). These include CVI, varicose veins, spider veins, leg ulcers, and phlebitis - a condition in which the leg veins become swollen ( 16).Ī 2012 review of 10 studies concluded that moderate evidence supports the use of MPFF (diosmin) to improve CVD symptoms, such as leg ulcers, edema, varicose veins, tingling sensation, general quality of life, and subjective pain ratings ( 16).Ī 2016 review and 2018 meta-analysis supported these findings. Chronic venous diseaseĬhronic venous disease (CVD) is an umbrella term for conditions related to weak or diseased veins. Overall, diosmin may not be as effective as other hemorrhoid treatments ( 11, 12, 14, 15). Though these results are promising, most improvements are seen in people in the early stages of hemorrhoid disease. Additionally, diosmin has been shown to reduce recovery time following a hemorrhoidectomy, or surgical removal of hemorrhoids ( 3, 11, 12, 13). Other studies reveal similar improvements in hemorrhoid symptoms. In a review of 24 studies in over 2,300 people, plant flavonoids like diosmin decreased hemorrhoid-related itchiness, bleeding, discharge, and other hemorrhoid symptoms ( 10). Numerous studies suggest that diosmin helps treat internal and external hemorrhoids. Research suggests that this compound may reduce inflammation in the veins and thus improve blood flow ( 2). People may also take diosmin for other blood vessel disorders, including varicose veins, blood clots, retinal hemorrhage (bleeding in the retina of the eye), venous leg ulcers, and venous stasis (slow blood flow in the legs) ( 8, 9). Hemorrhoids are swollen veins located near the anus, while CVI refers to swollen, blocked veins in the legs ( 6, 7). Depending on your location, it may be called Diovenor, Daflon, Barosmin, citrus flavonoids, Flebosten, Litosmil, or Venosmine ( 4, 5).ĭiosmin is most widely used to treat blood vessel disorders, such as hemorrhoids and chronic venous insufficiency (CVI). This supplement is available over the counter in the United States, Canada, and some European countries. In most cases, the terms “diosmin” and “MPFF” are used interchangeably ( 3). Most diosmin supplements contain 90% diosmin with 10% hesperidin and are labeled MPFF. Today, diosmin is widely derived from another flavonoid called hesperidin, which is also found in citrus fruits - especially orange rinds ( 2).ĭiosmin is often combined with micronized purified flavonoid fraction (MPFF), a group of flavonoids that includes disomentin, hesperidin, linarin, and isorhoifolin ( 3). It’s believed to help reduce inflammation and restore normal blood flow in people with venous insufficiency, a condition in which blood flow is impaired ( 2). Diosmin was first isolated from the figwort plant ( Scrophularia nodosa L.) in 1925 and has been used since 1969 as a natural therapy to treat various conditions, such as hemorrhoids, varicose veins, venous insufficiency, leg ulcers, and other circulatory issues ( 2).
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